| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375929 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of N-arylpiperazine camphor sulfonamides was discovered as novel CXCR3 antagonists. The synthesis, structure–activity relationships, and optimization of the initial hit that resulted in the identification of potent and selective CXCR3 antagonists are described.
Graphical abstractA series of N-arylpiperazine camphor sulfonamides was discovered as novel CXCR3 antagonists. The synthesis, structure–activity relationships, and optimization of the initial hit that resulted in the identification of potent and selective CXCR3 antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yonghui Wang, Jakob Busch-Petersen, Feng Wang, Terence J. Kiesow, Todd L. Graybill, Jian Jin, Zheng Yang, James J. Foley, Gerald E. Hunsberger, Dulcie B. Schmidt, Henry M. Sarau, Elizabeth A. Capper-Spudich, Zining Wu, Laura S. Fisher,