| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375933 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (−)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.
Graphical abstractThe design, synthesis, and biological activity of a series of aryl substituted 2,2,5-disubstituted pyrrolidines that are structurally related to the known ionotropic glutamate receptor antagonist, (−)-kaitocephalin, is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Rishi G. Vaswani, Agenor Limon, Jorge Mauricio Reyes-Ruiz, Ricardo Miledi, A. Richard Chamberlin,