| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375955 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haile Tecle, Jianxing Shao, Yanhong Li, Michael Kothe, Steven Kazmirski, Julie Penzotti, Yuan-Hua Ding, Jeffrey Ohren, Deb Moshinsky, Rocco Coli, Nidhi Jhawar, Emilia Bora, Suzanne Jacques-O’Hagan, Joe Wu,