| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375963 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
We describe herein the medicinal chemistry approach which led to the discovery of a novel pyridine-3-carboxamide series of CB2 receptor agonists. The SAR of this new template was evaluated and culminated in the identification of analogue 14a which demonstrated efficacy in an in vivo model of inflammatory pain.
Graphical abstractThe synthesis and biological profile of the pyridine-3-carboxamide 14a and related analogues are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
William L. Mitchell, Gerard M.P. Giblin, Alan Naylor, Andrew J. Eatherton, Brian P. Slingsby, Anthony D. Rawlings, Karamjit S. Jandu, Carl P. Haslam, Andrew J. Brown, Paul Goldsmith, Nick M. Clayton, Alex W. Wilson, Iain P. Chessell, Richard H. Green,