Article ID Journal Published Year Pages File Type
1375978 Bioorganic & Medicinal Chemistry Letters 2005 4 Pages PDF
Abstract

Thienylpyrimidines substituted at position 2 of the pyrimidine with a chiral aminoalkoxy group were synthesized. Upon interaction with duplex DNA, the unfused heteroaromatic system of these compounds intercalates with DNA base pairs and the protonated side chain is located in the major groove. The S-enantiomers bind more strongly than their R-counterparts with enantiomeric discrimination, as measured by a ratio of binding constants KS/KR, ranging from 1.2 to 2.4.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , ,