Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375978 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Thienylpyrimidines substituted at position 2 of the pyrimidine with a chiral aminoalkoxy group were synthesized. Upon interaction with duplex DNA, the unfused heteroaromatic system of these compounds intercalates with DNA base pairs and the protonated side chain is located in the major groove. The S-enantiomers bind more strongly than their R-counterparts with enantiomeric discrimination, as measured by a ratio of binding constants KS/KR, ranging from 1.2 to 2.4.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lucjan Strekowski, Marek T. Cegla, Vidya Honkan, Henryk Buczak, W. Rucks Winkeljohn, Alfons L. Baumstark, W. David Wilson,