| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375981 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Corey R. Hopkins, Mark Czekaj, Steven S. Kaye, Zhongli Gao, James Pribish, Henry Pauls, Guyan Liang, Keith Sides, Dona Cramer, Jennifer Cairns, Yongyi Luo, Heng-Keang Lim, Roy Vaz, Sam Rebello, Sebastian Maignan, Alain Dupuy, Magali Mathieu,