| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375990 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Two new bisindole alkaloids, 6-hydroxystaurosporinone (1) and 5,6-dihydroxyarcyriaflavin A (2) were isolated from field-collected fruit bodies of a myxomycete Lycogala epidendrum, along with eight known bisindoles (3–10). The structures of these new compounds were determined on the basis of spectroscopic data. Compounds 1 and 2 showed cytotoxicity against HeLa, Jurkat, and vincristine resistant KB/VJ300 cells, and compound 1, particularly, inhibited protein tyrosine kinase activity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takahiro Hosoya, Yukinori Yamamoto, Yoshimasa Uehara, Masahiko Hayashi, Kanki Komiyama, Masami Ishibashi,