| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375994 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Dihydroindenoisoquinolines are analogs of cytotoxic indenoisoquinoline topoisomerase I (Top1) inhibitors, exhibiting potent cytotoxicity but weak inhibitory activity toward Top1. Through COMPARE analysis, cytotoxicity studies in Top1-deficient cells, chemical synthesis and biological evaluation of methylated dihydroindenoisoquinoline 5, we demonstrated that dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines in cancer cells.
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Related Topics
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Authors
Xiangshu Xiao, Ze-Hong Miao, Smitha Antony, Yves Pommier, Mark Cushman,