Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375996 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The synthesis and structure–activity relationship of a series of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as novel non-nucleoside adenosine kinase inhibitors is described. A variety of substituents, primarily aryl, at the C6 and C7 positions of the pyridopyrimidine core were found to yield analogues that are potent inhibitors of adenosine kinase. In contrast to the 5,7-disubstituted and 5,6,7-trisubstituted pyridopyrimidine series, these analogues exhibited only modest potency to inhibit AK in intact cells.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Richard J. Perner, Chih-Hung Lee, Meiqun Jiang, Yu-Gui Gu, Stanley DiDomenico, Erol K. Bayburt, Karen M. Alexander, Kathy L. Kohlhaas, Michael F. Jarvis, Elizabeth L. Kowaluk, Shripad S. Bhagwat,