| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376001 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5′-moieties and are shown to have different kcat/Km values compared with the natural MTAP substrate (MTA).
Graphical abstractThe structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5′-moieties and are shown to have different kcat/Km values compared with the natural MTAP substrate (MTA).Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pei-Pei Kung, Luke R. Zehnder, Jerry J. Meng, Stanley W. Kupchinsky, Donald J. Skalitzky, M. Catherine Johnson, Karen A. Maegley, Anne Ekker, Leslie A. Kuhn, Peter W. Rose, Laura A. Bloom,