| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376004 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
Antioxidant activities for a series of hydroxybenzalacetones, OH-BZ, evaluated by their inhibitory potencies against lipid peroxidation induced by γ-irradiation or BuOOH (tert-butyl hydroperoxide), were analyzed quantitatively using quantum-chemical parameters calculated by semi-empirical molecular orbital (MO) calculations.log(1/IC50)=f(EHOMO,FH,O,Es)EHOMO: HOMO energy, FH,O: frontier electron densities (HOMO) on the phenolic oxygen atom(s), Es: steric parameter for the ortho substituent
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Authors
Chisako Yamagami, Miki Akamatsu, Noriko Motohashi, Shogo Hamada, Takao Tanahashi,