| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376010 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan® technology, a new lead series was identified and further structurally investigated. Ki’s as low as around 100 nM were achieved.
Graphical abstractSynthesis and SAR studies of non-competitive mGluR5 antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefan Tasler, Jürgen Kraus, Stefano Pegoraro, Andrea Aschenbrenner, Elena Poggesi, Rodolfo Testa, Gianni Motta, Amedeo Leonardi,