| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376016 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
An array of analogues of the cationic antimicrobial peptide drosocin was synthesized containing substitutions of Tyr6 and Ser7 in order to increase the proteolytic stability. Stabilizing the N-terminus with unnatural amino acids increased the serum stability of analogues by almost a factor 30 over an 8 h period.
Graphical abstractAn array of analogues of the cationic antimicrobial peptide drosocin was synthesized containing substitutions of Tyr6 and Ser7 in order to increase the proteolytic stability. Stabilizing the N-terminus with unnatural amino acids increased the serum stability of analogues by almost a factor 30 over an 8 h period.
Related Topics
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Authors
Peter C. de Visser, Peter A.V. van Hooft, Anne-Marij de Vries, Ad de Jong, Gijsbert A. van der Marel, Herman S. Overkleeft, Daan Noort,