| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376024 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
An enzyme labeling and screening strategy for the discovery of ligands selective in binding two structurally similar members of the aldo-keto reductase family of enzymes is reported. The resulting fluorescence microscope data obtained by screening a 74,088 member library led to the identification of selective ligands for aldose reductase (ALR2) and aldehyde reductase (ALR1). Resynthesis results validate the selectivity of these ligands.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Seth Dixon, Lori Robins, Robert A. Elling, Ruiwu Liu, Kit S. Lam, David K. Wilson, Mark J. Kurth,