Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376038 | Bioorganic & Medicinal Chemistry Letters | 2007 | 7 Pages |
Abstract
The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of 5 confirmed the proposed mode of binding. The potent single digit DPP-IV inhibitor 53 exhibited a preferred PK/PD profile in preclinical animal models and was selected for additional profiling.
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Related Topics
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Organic Chemistry
Authors
J.W. Corbett, K. Dirico, W. Song, B.P. Boscoe, S.D. Doran, D. Boyer, X. Qiu, M. Ammirati, M.A. VanVolkenburg, R.K. McPherson, J.C. Parker, E.D. Cox,