| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376041 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A urea class of high affinity niacin receptor agonists was discovered. Compound 1a displayed good PK, better in vivo efficacy in reducing FFA in mouse than niacin, and no vasodilation in a mouse model. Compound 1q demonstrated equal affinity to GPR109A as niacin.
Graphical abstractA urea class of high affinity niacin receptor agonists was discovered. Compound 1a displayed good PK, better in vivo efficacy in reducing FFA in mouse than niacin, and no vasodilation in a mouse model. Compound 1q also demonstrated equal affinity to GPR109A as niacin.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Hong C. Shen, Michael J. Szymonifka, Divya Kharbanda, Qiaolin Deng, Ester Carballo-Jane, Kenneth K. Wu, Tsuei-Ju Wu, Kang Cheng, Ning Ren, Tian-Quan Cai, Andrew K. Taggart, Junying Wang, Xinchun Tong, M. Gerard Waters, Milton L. Hammond, James R. Tata,