Article ID Journal Published Year Pages File Type
1376056 Bioorganic & Medicinal Chemistry Letters 2007 5 Pages PDF
Abstract
Development of a lead series of piperidinylurea CXCR3 antagonists has led to the identification of molecules with alternative linkages, which retain good potency. A piperidinyl thiadiazole derivative was found to have satisfactory in vitro metabolic stability and to be orally bioavailable in mice, giving high plasma concentrations and a half life of 5.4 h.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , , , ,