| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376063 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa, and delta receptors. Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors.
Graphical abstractA series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa and delta receptors. Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kumiko Takeuchi, William G. Holloway, Charles H. Mitch, Steven J. Quimby, Jamie H. McKinzie, Todd M. Suter, Michael A. Statnick, Peggy L. Surface, Paul J. Emmerson, Elizabeth M. Thomas, Miles G. Siegel,