| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376065 | Bioorganic & Medicinal Chemistry Letters | 2007 | 7 Pages |
A series of 17 symmetrical substituted imidothiocarbamate and imidoselenocarbamate derivatives has been synthesized by reacting appropriately substituted acyl chlorides with alkyl imidothiocarbamates and alkyl imidoselenocarbamates. The antitumoral activities of the compounds were evaluated in vitro by examining their cytotoxic effects against human prostate cancer cells (PC-3). Five compounds showed interesting activity levels and 3p (IC50 = 1.85 μM) was 7.3 times more active than the standard etoposide used in the treatment of prostate cancer and emerges as the most interesting compound.
Graphical abstractSignificant in vitro antiproliferative activity against human prostate cancer cell (PC-3) of novel symmetrical imidoselenocarbamates is showed.Figure optionsDownload full-size imageDownload as PowerPoint slide
