| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376068 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
To identify novel inhibitors of tyrosinase, a fluorescent assay was developed which is suitable for high-throughput screening. In the assay, oxidation of the substrate by tyrosinase leads to the release of a fluorescent coumarin. Several small molecules were identified that inhibited mushroom tyrosinase in vitro and human tyrosinase in cell culture. These compounds may represent lead structures for therapies targeted at disorders of hyperpigmentation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Juris P. Germanas, Shugauang Wang, Andrew Miner, Wayne Hao, Joseph M. Ready,