| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376077 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Several P4 domain derivatives of the d-phenylglycinamide-based scaffold (2) were synthesized and evaluated for their ability to bind to the serine protease factor Xa. Some of the more potent compounds were evaluated for their anticoagulant effects in vitro. An additional subset containing various P1 indole constructs was evaluated for their oral exposure properties.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffry B. Franciskovich, John J. Masters, Wayne W. Weber, Valentine J. Klimkowski, Michael Chouinard, Philip R. Sipes, Lea M. Johnson, David W. Snyder, Marcia K. Chastain, Trelia J. Craft, Richard D. Towner, Donetta S. Gifford-Moore, Larry L. Froelich,