| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376123 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A series of 4-(4-hydroxyphenyl)-6-phenylpyrimidin-2(1H)-ones were identified by HTS as inhibitors of CDC7. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus on removing potential metabolic liabilities and improving cellular potency.
Graphical abstractA series of 4-(4-hydroxyphenyl)-6-phenylpyrimidin-2(1H)-ones were identified by HTS as inhibitors of CDC7. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus on removing potential metabolic liabilities and improving cellular potency.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cynthia M. Shafer, Mika Lindvall, Cornelia Bellamacina, Thomas G. Gesner, Asha Yabannavar, Weiping Jia, Song Lin, Annette Walter,