| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376141 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Efficient syntheses of folate conjugates of tubulysins and their hydrazides 1a–d are described. These water soluble folate receptor (FR) targeted conjugates are derivatives of folic acid and the potent cytotoxic agents: tubulysin A, B, or their respective hydrazides, connected in regioselective manner via a hydrophilic peptide spacer and a reducible disulfide linker.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Iontcho R. Vlahov, Yu Wang, Paul J. Kleindl, Christopher P. Leamon,