| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376145 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A focused SAR exploration of the lead 4-aminoquinazoline TRPV1 antagonist 2 led to the discovery of compound 18. In rats, compound 18 is readily absorbed following oral dosing and demonstrates excellent in vivo potency and efficacy in an acute inflammatory pain model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Charles A. Blum, Xiaozhang Zheng, Harry Brielmann, Kevin J. Hodgetts, Rajagopal Bakthavatchalam, Jayaraman Chandrasekhar, James E. Krause, Daniel Cortright, David Matson, Marci Crandall, Chu K. Ngo, Lawrence Fung, Marta Day, Mark Kershaw,