| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376150 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG2000-DSPE (OPD2000) was used as an example to demonstrate the synthetic approach. The OPD2000 obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
Graphical abstractChemical structure of Octreotide-PEG-DSPE.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jian-Chiou Su, Chin-Lu Tseng, Ting-Gung Chang, Wen-Jen Yu, Shih-Kwang Wu,