Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376160 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
In order to study the effect of 5′-modification of 2′-deoxynucleoside on its anti-HCV activity, several analogues were synthesized and evaluated. Among the analogues, a 5′-deoxy-5′-phenacylated analogue exhibited a good anti-HCV activity with an EC50 of 15.1 μM. This compound is expected to operate via a type of mechanism that does not involve a generally known 5′-O-triphosphorylation process.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masahiro Ikejiri, Takayuki Ohshima, Akemi Fukushima, Kunitada Shimotohno, Tokumi Maruyama,