| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376166 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Based on our pharmacophore model of the aryl diketoacids (ADKs), we designed and prepared a series of novel ADK analogues, which showed potent inhibitory activities against the NS5B polymerase in the submicromolar range. Pharmacophore-guided docking study revealed that the antiviral activities of the ADKs are highly dependent upon the aryl linker as well as the size and position of the aromatic substituent. It is of another importance that, unlike previously reported ADKs, three ADK analogues synthesized in this study effectively blocked Hepatitis C Virus (HCV) replication in the replicon systems.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jinyoung Kim, Ki-Sun Kim, Hyo Seon Lee, Kwang-Su Park, Sun Young Park, Seock-Yong Kang, Soo Jae Lee, Hyung Soon Park, Dong-Eun Kim, Youhoon Chong,