Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376181 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Aminocyclohexyl indoles bind with high affinity and specificity toward the serotonin transporter (SERT). Based on this structural lead, we designed fluoroalkoxydihydroisoquinoline-cyclohexyl indole carbonitriles for future application as 18F-labeled tracers for SERT imaging by PET. Six compounds, three pairs of cis- and trans-isomer derivatives, respectively, were synthesized and evaluated in vitro. The chemistry of the new compounds, their affinity and specificity data, the general route to the phenolic precursor for labeling, and the successful 18F-fluoroalkylation of one pair of compounds are described herein.
Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Uta Funke, Steffen Fischer, Achim Hiller, Matthias Scheunemann, Winnie Deuther-Conrad, Peter Brust, Jörg Steinbach,