| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376183 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
An efficient synthesis of the acid part of salvianolic acid E 2 is described. Compound 2 was obtained from vanillin in 10 steps and 21% overall yield. During the synthesis of 2 an unexpected 5-oxo-4b,9b-dihydroindano[1,2-b]benzofuran rac-12 was isolated. Both compounds together with the acid part of salvianolic acid D were active as HIV-1 integrase inhibitors at the submicromolar level. But they did not inhibit the replication of the virus on MT-4 cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Clémence Queffélec, Fabrice Bailly, Gladys Mbemba, Jean-François Mouscadet, Sean Hayes, Zeger Debyser, Myriam Witvrouw, Philippe Cotelle,