| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376184 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Novel 1-O- and 14-O-derivatives of oridonin were synthesized and biologically evaluated. All of the derivatives exhibited stronger cytotoxicity against six cancer cell lines (BGC-7901, SW-480, HL-60, BEL-7402, A549, and B16) than oridonin in vitro, and some of them were more potent than oridonin and cyclophosphamide in vivo. Compounds Ib and IIg were the most potent with the IC50 values of 0.84 μM for Ib in HL-60 cell and 1.00 μM for IIg in BEL-7402 cell.
Graphical abstract1-O- and 14-O-derivatives of oridonin exhibited stronger cytotoxicity against six cancer cell lines than oridonin in vitro, compounds Ib and IIg were more potent than oridonin and cyclophosphamide in vivo.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Chemistry
Organic Chemistry
Authors
Jinyi Xu, JingYi Yang, Qian Ran, Lei Wang, Jie Liu, Zhixuan Wang, Xiaoming Wu, Weiyi Hua, Shengtao Yuan, Luyong Zhang, Mingqin Shen, Yongfang Ding,