| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376193 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure–activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.
Graphical abstractNec-7, a new necroptosis inhibitor and its structural modification.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Weihong Zheng, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan,