Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376194 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
High throughput screening of our compound collection led to the discovery of a novel series of N-alkyl-5H-pyrido[4,3-b]indol-1-amines as urotensin-II receptor antagonists. Synthesis, initial structure and activity relationships, functional and animal ortholog activities of the series are described.
Synthesis, structure and activity relationships, functional and animal ortholog activities of a novel class of urotensin-II receptor antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yonghui Wang, Zining Wu, Brian F. Guida, Sarah K. Lawrence, Michael J. Neeb, Ralph A. Rivero, Stephen A. Douglas, Jian Jin,