| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376195 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A new route for the stereoselective synthesis of iodinated reboxetine analogues has been developed for the generation of SPECT imaging agents for the noradrenaline transporter (NAT). (2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT.
Graphical abstract(2S,3S)- and (2R,3R)-iodoreboxetine analogues have been prepared in a stereoselective manner and biological testing against various mono-amine transporters have shown these compounds to be potent and selective for the noradrenaline transporter.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Nicola K. Jobson, Andrew R. Crawford, Deborah Dewar, Sally L. Pimlott, Andrew Sutherland,