| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376196 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark I. Lansdell, Denise J. Burring, David Hepworth, Matthew Strawbridge, Emily Graham, Thierry Guyot, Mark S. Betson, James D. Hart,