| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376197 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Pyrazolopyrimidines were discovered as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. In addition to its intrinsic activity, compound 9n significantly enhances nicotinic acid binding to the receptor, thereby potentiating the functional efficacy of nicotinic acid.
Graphical abstractPyrazolopyrimidines were discovered as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. In addition to its intrinsic activity, compound 9n significantly enhances nicotinic acid binding to the receptor, thereby potentiating the functional efficacy of nicotinic acid.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hong C. Shen, Andrew K.P. Taggart, Larissa C. Wilsie, M. Gerard Waters, Milton L. Hammond, James R. Tata, Steven L. Colletti,