| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376209 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Among these, compound 4c displayed potent inhibitory activities in biochemical and replicon assays (IC50 (1b) <10 nM; EC50 (1b) = 34 nM) as well as good stability towards human liver microsomes (HLM t1/2 = 59 min).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Frank Ruebsam, Zhongxiang Sun, Benjamin K. Ayida, Stephen E. Webber, Yuefen Zhou, Qiang Zhao, Charles R. Kissinger, Richard E. Showalter, Amit M. Shah, Mei Tsan, Rupal Patel, Laurie A. LeBrun, Ruhi Kamran, Maria V. Sergeeva, Darian M. Bartkowski,