Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376213 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Anthranilic acid GW9371 was identified as a novel class of PPARδ partial agonist through high-throughput screening. The design and synthesis of SAR analogues is described. GSK1115 and GSK7227 show potent partial agonism of the PPARδ target genes CPT1a and PDK4 in skeletal muscle cells.
Graphical abstractThe discovery and evaluation of a novel anthranilic acid class of PPARδ partial agonists is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Barry G. Shearer, Hari S. Patel, Andrew N. Billin, James M. Way, Deborah A. Winegar, Millard H. Lambert, Robert X. Xu, Lisa M. Leesnitzer, Raymond V. Merrihew, Stephane Huet, Timothy M. Willson,