Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376214 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro.
Graphical abstractWe report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mike Frohn, Vellarkad Viswanadhan, Alexander J. Pickrell, Jennifer E. Golden, Kristine M. Muller, Roland W. Bürli, Gloria Biddlecome, Sean C. Yoder, Norma Rogers, Jennifer H. Dao, Randall Hungate, Jennifer R. Allen,