Article ID Journal Published Year Pages File Type
1376215 Bioorganic & Medicinal Chemistry Letters 2008 5 Pages PDF
Abstract

The design, synthesis, and structure–activity studies of a novel series of BK B1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B1 receptor were discovered.

Graphical abstractThe design, synthesis, and structure–activity studies of a novel series of BK B1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat BK B1 receptor were discovered.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Organic Chemistry
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