Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376215 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
The design, synthesis, and structure–activity studies of a novel series of BK B1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B1 receptor were discovered.
Graphical abstractThe design, synthesis, and structure–activity studies of a novel series of BK B1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat BK B1 receptor were discovered.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qin Guo, Jayaraman Chandrasekhar, David Ihle, David J. Wustrow, Bertrand L. Chenard, James E. Krause, Alan Hutchison, Dawn Alderman, Charles Cheng, Daniel Cortright, Daniel Broom, Mark T. Kershaw, Jean Simmermacher-Mayer, Yao Peng, Kevin J. Hodgetts,