| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376216 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A series of non-imidazole histamine H3 receptor antagonists based on the (3-phenoxypropyl)amine motif, which is a common pharmacophore for H3 antagonists, has been identified. A preliminary SAR study around the amine moiety has identified 8a as a potent H3 antagonist possessing a good pharmacokinetic profile in the rat.
Graphical abstractA series of non-imidazole histamine H3 receptor antagonists based on the (3-phenoxypropyl)amine motif have been identified. Compound 8a displays a good pharmacokinetic profile in the rat.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert Aslanian, Xiaohong Zhu, Henry A. Vaccaro, Neng-Yang Shih, John J. Piwinski, Shirley M. Williams, Robert E. West Jr.,