| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376221 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
PNA/DNA interstrand cross-links (ICLs) were observed when peptide nucleic acids (PNAs) containing modified thymine derivatives were hybridized with the complementary or one-base mismatched DNA upon photolysis or treatments of oxidative agent. PNA/DNA ICL formation provides a useful method for biological applications such as antisense technologies or PNA chips.
Graphical abstractPNA/DNA interstrand cross-links were formed from modified PNA base upon photolysis or oxidative conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yongtae Kim, In Seok Hong,