| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376222 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
A new series of betulinic acid derivatives have been synthesized by introducing heterocyclic ring between C-2 and C-3 positions of betulinic acid. Further modifications were also carried out by reduction of C-20(29) unsaturated bond and substitution of C-28 carboxyl group by ester and amide linkage to enhance the selectivity. Compound 11 resulted in IC50 of 2.44, 2.5, and 2.7 μg/ml on MIAPaCa, PA-1, and SW620 cancer cell lines, respectively. Compound 38 resulted in IC50 of 0.67 μg/ml on MIAPaCa cell line.
Graphical abstractA new series of betulinic acid derivatives have been synthesized by introducing heterocyclic ring between C-2 and C-3 positions of betulinic acid. Compound 11 has showed IC50 of 2.44, 2.5, and 2.7 μg/ml on MIAPaCa, PA-1, and SW620 cancer cell lines, respectively. While compound 38 showed IC50 of 0.67 μg/ml on MIAPaCa cell line.Figure optionsDownload full-size imageDownload as PowerPoint slide
