| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376229 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.
Graphical abstractThe synthesis and structure–activity relationship of a novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Kim M. Hutchings, Tuan P. Tran, Edmund L. Ellsworth, Brian M. Watson, Joseph P. Sanchez, H.D. Hollis Showalter, Michael A. Stier, Martin Shapiro, E. Themis Joannides, Michael Huband, Dai Q. Nguyen, Samarendra Maiti, Tingsheng Li, Jyoti Tailor,