Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376230 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Several adamantane-based taxol mimetics were synthesized and found to be cytotoxic at micromolar concentrations and to cause tubulin aggregation. The extent of the aggregation is maximal for N-benzoyl-(2R,3S)-phenylisoseryloxyadamantane (5) and is very sensitive to the structural modifications. A hybrid compound (15), combining adamantane-based taxol mimetic with colchicine was synthesized and found to possess both microtubule depolymerizing and microtubule bundling activities in A549 human lung carcinoma cells.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Olga N. Zefirova, Evgeniya V. Nurieva, Heiko Lemcke, Andrei A. Ivanov, Dmitrii V. Shishov, Dieter G. Weiss, Sergei A. Kuznetsov, Nikolay S. Zefirov,