| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376238 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay.
Graphical abstractPotent PARP-1 inhibitors were identified in a tricyclic pyrazolo pyridine-2-one series with nanomolar binding affinity and submicromar activity in a cell-based chemosensitization assay.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wilna J. Moree, Phyllis Goldman, Anthony J. Demaggio, Erik Christenson, Dan Herendeen, John Eksterowicz, Edward A. Kesicki, David L. McElligott, Graham Beaton,