Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376255 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Here we describe the inhibitory activity toward neutral aminopeptidase of three new families of phosphinate inhibitors related in structure to hydroxamic acids. These compounds, even as racemic mixtures, are good inhibitors of APN and show strong structure activity relationship (SAR) depending on the substituents in P1 and P1′ positions.
Graphical abstractNew phosphinate inhibitors of aminopeptidase N are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marcin Drag, Renata Grzywa, Jozef Oleksyszyn,