| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376268 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Potential prodrugs of inhibitors of VEGF-induced angiogenesis have been investigated. The prodrug systems studied were the 4-nitrobenzyl, 2-nitrophenylacetyl and 3-methyl-3-(3,6-dimethylbenzo-1,4-quinon-2-yl)butanoyl groups, readily attached to acidic OH or NH groups in drug molecules, and released upon bioreductive activation. The anti-angiogenic compounds studied were the pyrrolylmethylidenyl oxindole SU5416 (semaxanib) and its novel 6-hydroxy derivative. The potentially pro-anti-angiogenic compounds were assayed for their ability to block VEGF-induced angiogenesis in HUVECS in comparison to the free agents.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Lesley Maskell, Emilie A. Blanche, Marie A. Colucci, Jacqueline L. Whatmore, Christopher J. Moody,