| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376269 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 μM when tested in combination with paclitaxel.
Graphical abstractA small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 μM when tested in combination with paclitaxel.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maurizio Botta, Silvia Armaroli, Daniele Castagnolo, Gabriele Fontana, Paula Pera, Ezio Bombardelli,