| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376271 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Sleeping sickness caused by Trypanosoma brucei gambiense and rhodesiense is fatal if left untreated. Due to the toxicity of drugs currently used and the emerging resistance against these drugs new lead compounds are urgently needed. Within the frame of a broad screening program for drugs with antitrypanosomal activity, some highly potent tertiary and quaternary mono- and bisnaphthalimides being active in the lower micromolar and nanomolar range of concentration have been identified. These compounds are easily available via a two- or three-step microwave-driven synthesis with high yield.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mathias Muth, Verena Hoerr, Melanie Glaser, Alicia Ponte-Sucre, Heidrun Moll, August Stich, Ulrike Holzgrabe,