Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376282 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Subtype-selective α-1a and/or α-1d adrenergic receptor antagonists may be useful for the treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) with fewer adverse effects than non-selective drugs. A series of 1-arylpiperazinyl-4-cyclohexylamine derived isoindole-1,3-diones has been synthesized, displaying in vitro α1a and α1d binding affinity Ki values in the range of 0.09–38 nM with Ki(α1b)/Ki(α1a) and Ki(α1b)/Ki(α1d) selectivity ratios up to 3607-fold.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shengjian Li, George Chiu, Virginia L. Pulito, Jingchun Liu, Peter J. Connolly, Steven A. Middleton,